Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer

Detecting DNA Methylation using the Oxford Nanopore Technologies MinION sequencer

Affiliations: 1 Ontario Institute for Cancer Research, Toronto, Canada 2 Department of Computer Science, University of Toronto, Toronto, Canada 3 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland Correspondence to: [email protected] [email protected] Abstract Nanopore sequencing instruments measure the change in electric current caused by DNA transi...

Characterization of a Solid State DNA Nanopore Sequencer Using Multi-scale (Nano-to-Device) Modeling

Nanobiotechnology is a rapidly advancing frontier of science with great potential for beneficial impact on society. Unfortunately, design of integrated nano-bio systems is a complex, laborious task with large failure rates. Current models describing molecular level behavior are expensive, while device design codes lack the necessary nanophysics. The objective of this work is to demonstrate mult...

Preimplantation Genetic Testing

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Preimplantation Genetic Testing

Preimplantation genetic testing (PGT) involves analysis of biopsied cells as part of an assisted reproductive procedure. It is generally considered to be divided into 2 categories. Preimplantation genetic diagnosis (PGD) is used to detect a specific inherited disorder and aims to prevent the birth of affected children in couples at high risk of transmitting a disorder. Preimplantation genetic s...

Preimplantation Genetic Testing